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Hepatogenic differentiated murine mesenchymal stem cells display functional qualities of perivenous and/or periportal hepatocytes

S Winkler, S Brückner, P Stock, M Hempel, B Christ · Zeitschrift für Gastroenterologie · 2014 · Heft 01

Dokument
1051811
CareLit-ID
Jahr
2014
Publikation
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
S Winkler, S Brückner, P Stock, M Hempel, B Christ
Ausgabe
Heft 01 / 2014
Seiten
–
Erschienen: 2014-01-13 00:00:00
ISSN
0044-2771
DOI
10.1055/s-0033-1360975

Zusammenfassung

Background: Mesenchymal stem cells possess the ability to differentiate into hepatocyte-like cells in vitro. Thus, they open the possibility for use as therapeutic alternative instead of hepatocyte or even whole organ transplantation in different chronic (metabolic) liver diseases such as e.g. alpha-1-antitrypsin deficiency. This study aimed to examine functional parameters of murine mesenchymal stem cells after hepatogenic differentiation in order to develop a pre-clinical assessment of their potential for clinical application in chronic liver disease models. Methods: Mesenchymal stem cells were isolated from m…

Schlagworte

After alpha 1-Antitrypsin Deficiency Alpha-1-Antitrypsin alpha 1-Antitrypsin Transplantation Zeitschrift für Gastroenterologie