Secondary resistances to measles virus (MeV)-based virotherapy
S Berchtold, T Weiland, J Lampe, I Smirnow, S Venturelli, A Berger, J Reiser, F Stubenrauch, NP Malek, M Bitzer, UM Lauer · Zeitschrift für Gastroenterologie · 2014 · Heft 01
Bibliografische Angaben
Zusammenfassung
Introduction: Oncolysis has a great potential in treating solid tumors. This is believed to be true also for tumors which have been demonstrated to be resistant to conventional chemotherapy and radiotherapy conclusions. The oncolytic potential of measles vaccine virus (MeV) has been shown both in vitro and in vivo. On the contrary, resistances to MeV-mediated oncolysis were demonstrated to either pre-exist or arise in the course of MeV virotherapy. To especially investigate mechanisms of secondary resistance we have generated a hepatoma cell line being persistently infected with MeV (MeV-RII_HepG2) which was gen…
