Tumor suppressive mechanisms in hepatocellular carcinoma through inhibition of IL-6 signaling

Hepatocellular carcinoma (HCC) is the most frequent malignant tumor in the liver and the third leading cause of cancer death worldwide (696,000 deaths, 9.2%). Although significant progress has been made in the HCC field, the molecular mechanisms and signaling pathways underlying HCC development and progression are still poorly understood. This is probably the case because HCC is very heterogeneous in terms of clinical presentation, genomic alterations and gene expression patterns. In a recent study, we applied an integrative approach of high-resolution array-based comparative genomic hybridization (arrayCGH) and…