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Deletion of Formyl-peptide receptors lead to an increased inflammatory response and enhanced liver injury following a bacterial induced hepatitis

A Giebeler, U Neumann, LO Brandenburg · Zeitschrift für Gastroenterologie · 2014 · Heft 01

Dokument
1051815
CareLit-ID
Jahr
2014
Publikation
PDF
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Metadaten
DOI
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Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
A Giebeler, U Neumann, LO Brandenburg
Ausgabe
Heft 01 / 2014
Seiten
–
Erschienen: 2014-01-13 00:00:00
ISSN
0044-2771
DOI
10.1055/s-0033-1361015

Zusammenfassung

Introduction: The Formyl-peptide-receptor 1 and the formyl-peptide-receptor 2 (FPR1 and FPR2) were identified as receptors with a different affinity for the pathogen-associated-molecular-pattern (PAMP) N-formylmethionyl-leucyl-phenylalanine (fMLF). The tripeptide fMLF is a component of the bacterial membrane. During apoptosis it is secreted by the mitochondria of eukaryotic cells. Furthermore FPR1 and 2 are described as highly relevant factors for the chemotaxis of monocytes and neutrophils. So far their role during the acute liver injury has not been investigated. Material and Methods: Constitutive knockout mic…

Schlagworte

Apoptosis Chemotaxis Blood After Lead Hepatitis Zeitschrift für Gastroenterologie