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Interferon stimulated gene 15, a proviral factor in hepatitis C virus replication, is regulated by the Proteasome subunit alpha type-6

R Broering, M Trippler, CI Real, M Lutterbeck, K Kleinehr, L Poggenpohl, G Gerken, JF Schlaak · Zeitschrift für Gastroenterologie · 2014 · Heft 01

Dokument
1051817
CareLit-ID
Jahr
2014
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
R Broering, M Trippler, CI Real, M Lutterbeck, K Kleinehr, L Poggenpohl, G Gerken, JF Schlaak
Ausgabe
Heft 01 / 2014
Seiten
–
Erschienen: 2014-01-13 00:00:00
ISSN
0044-2771
DOI
10.1055/s-0033-1361035

Zusammenfassung

Aim and Background: The interferon stimulated gene 15 (ISG15) plays an important role in the pathogenesis of hepatitis C virus (HCV) infection. We recently identified seven ISG15-regulated proteins, which putatively affect this proviral interaction. Therefore, the aim of this study was to further elucidate the relation between ISG15 and these proteins during HCV infection. Methods: Expression of selected ISGs (ISG15 and interferon-induced protein with tetratricopeptide repeats 1 (IFI-T1)) and ISG15-regulated genes (Medium-chain specific acyl-CoA dehydrogenase (ACADM), Heterogeneous nuclear ribonucleoprotein A3 (…

Schlagworte

Hepatitis Acyl-CoA Dehydrogenase Acyl-CoA-Dehydrogenase Affect Acyl-CoA Zeitschrift für Gastroenterologie