Effect of treatment with Roflumilast on quality of life in COPD patients: results from the DINO study (Daxas in COPD therapy)

Background Improvement of quality of life (QoL) is an important goal of COPD management. This single-arm, non-interventional study investigated the effects of add-on roflumilast (Rof) on QoL in routine medical practice by means of the Clinical COPD Questionnaire (CCQ). Also, data on tolerability of treatment with Rof and patients' mental state were collected. Methods A total of 5,375 patients (intention-to-treat, ITT) were treated with Rof 500 µg for up to 6 months. CCQ scores were measured at study start (V1), after 3 (V2) and 6 months (V3). Adverse drug reactions (ADRs) were recorded. The patients' mental stat…