Localisation of attentional function in Lewy body dementia and Alzheimer's disease

Question: Fluctuations in cognition and attention is a core symptom of Lewy Body Dementia (LBD). Yet the aetiology of this symptom is incompletely understood but may relate to fronto-parietal network dysfunction. Therefore we examined the performance and brain activation in LBD patients applying a modified ANT (attention network task) using an event-related functional magnetic resonance (fMRI) paradigm and compared those activations with healthy controls and patients with Alzheimer's disease (AD). Methods: 19 LBD patients, 25 AD patients and 23 age-matched healthy controls (HC) underwent an assessment of global…