BoNT/D is effective in humans – but with higher dosing and shorter duration than BoNT/A
K Wohlfarth, T Fiedler, K Kollewe, F Wegner, J Weisemann, G Adeli, S Alvermann, S Böselt, C Escher, N Garde, S Gingele, SB Kaehler, R Karatschai, T Krüger, T Schmidt, S Sikorra, P Tacik, J Wollmann, R Dengler, H Bigalke, A Rummel · Klinische Neurophysiologie · 2014 · Heft 03
Bibliografische Angaben
Zusammenfassung
Objective: The seven serotypes A-G of botulinum neurotoxins (BoNT) are extremely potent poisons but also highly effective medicines to treat hyperactive cholinergic neurons in different diseases and symptoms such as dystonias, spasticity, pain and hyperhidrosis. However, during long-term treatment patients may become non-responsive to the approved BoNT/A and B due to antibody formation. The remaining serotypes C-G might display treatment alternatives. BoNT/D is least related with A and B thereby circumventing neutralisation in A/B non-responder. Interestingly, no human intoxication has been reported with BoNT/D.…
