CD40-TRAF6 pathway as a therapeutic target in obesity-associated metabolic dysfunction
A Chatzigeorgiou, T Seijkens, B Zarzycka, D Engel, M Poggi, KJ Chung, R Garcia Martin, E Lutgens, T Triantafyllos · Diabetologie und Stoffwechsel · 2014 · Heft 05
Bibliografische Angaben
Zusammenfassung
Objective: Inflammation contributes to the pathogenesis of obesity-associated metabolic dysregulation and co-stimulatory molecules, including CD40, are important mediators of this process. This study aimed to reveal the role of CD40 and its signaling intermediates, TNF-Receptor-Associated-Factors (TRAFs), in diet-induced obesity (DIO). Methods: The DIO model was performed in CD40-deficient or -sufficient mice as well as in mice with deficient CD40-TRAF2/3/5- or CD40-TRAF6-signaling in MHCII+ cells. Several metabolic parameters were measured and subcutaneous and gonadal adipose tissues (AT) and liver were isolate…
