Promoter methylation of TMEM18 in subcutaneous adipose tissue is related to glucose homeostasis
K Rohde, M Keller, M Klös, D Schleinitz, A Dietrich, MR Schön, D Gärtner, T Lohmann, M Dreßler, M Stumvoll, P Kovacs, M Blüher, Y Böttcher · Diabetologie und Stoffwechsel · 2014 · Heft 05
Bibliografische Angaben
Zusammenfassung
Context: Epigenetic processes such as dynamic promoter methylation may play a role in obesity, fat distribution and its accompanied metabolic alterations. TMEM18 is a candidate gene for BMI comprising the second largest effect size among all loci identified so far via GWAS. Objective: We hypothesized that differential TMEM18 gene expression in visceral (VAT) and subcutaneous adipose tissue (SAT) may be a consequence of depot specific differential methylation at the TMEM18 promoter region. Differential methylation levels may confer fat depot specific correlations with measures of obesity and fat distribution. Des…
