T-helper lymphocyte subpopulations in type 1 diabetes: influence of the vitamin D status and CYP24A1 single nucleotide polymorphism
V Harant, M Penna-Martinez, D Bogdanou, J Schwartz, C Brehm, S Hünecke, U Köhl, F Shoghi, S Wicker, K Badenhoop · Diabetologie und Stoffwechsel · 2014 · Heft 05
Bibliografische Angaben
Zusammenfassung
Introduction: Imbalance in T-cell subpopulations plays a critical role for the development of type 1 diabetes (T1D) whereas 25(OH)D3 has a protective role. We aimed to investigate whether T-helper lymphocyte subpopulations correlate with 25(OH)D3 status and CYP24A1 (rs2296241) single nucleotide polymorphism (SNP), a 25(OH)D3 metabolizing enzyme, in T1D patients and healthy controls (HC). Methods: EDTA-blood samples of 28 T1D patients and 28 age-matched HC were collected during summer period. Flow cytometric analysis was performed to determine the absolute and percentage of following T-helper cell subpopulations:…
