Effects of linagliptin on glucose-induced neuronal damage on Caenorhabditis elegans

Introduction: C. elegans lacks a vascular system and is therefore an ideal model system to investigate the mechanisms of glucose-mediated damage to neurons. Experimental hyperglycaemia causes neuronal dysfunction in C. elegans and reduces lifespan by overproduction of ROS and MG-derived AGEs. A key regulator for longevity and stress response is DAF-16, which up-regulates MnSOD, an enzyme detoxifying ROS. Here we used wild-type and daf-16 strains to study the potential molecular mechanisms underlying the effects of linagliptin on C. elegans with relation to the diabetic retina. Method: A total of 150 – 300 C. ele…