GLP-1 (7 – 37) and the GLP-1 metabolite (9 – 37) improve myocardial function and reduce infraction size after LAD ligation

Purpose: GLP-1 (7 – 37) is an incretin hormone which is released in response to nutritional stimuli from the gut and improves glucose metabolism by increasing glucose dependent insulin secretion. Furthermore, GLP-1 (7 – 37) has cardio protective effects and was found to reduce myocardial infarction size and improve contractile function following ischemia. Similar cardio protective effects have been reported for the GLP-1 metabolite (9 – 37) under in vitro conditions. Methods and Results: To evaluate whether the GLP-1 metabolite (9 – 37) has cardioprotective function also under in vivo conditions we overexpressed…