Acute phase protein α1-Antitrypsin – a novel regulator of angiopoietin-like protein 4 transcription and secretion

The angiopoietin-like protein 4 (angptl4, also known as peroxisome proliferator-activated receptor (PPAR) gamma induced angiopoietin-related protein) is a multifunctional protein associated with acute phase response. The mechanisms accounting for the increase in angptl4 expression are largely unknown. This study is the first to show that human α1-antitrypsin (A1AT) up-regulates expression and release of angplt4 in human blood adherent mononuclear cells and in primary human lung microvascular endothelial cells in a concentration- and time-dependent manner. Mononuclear cells treated for 1h with A1AT (from 0.1 to 4…