Therapeutic effects of fibroblast grow factor 10 (FGF 10) after hyperoxic lung injury in mice

Background and aims: Bronchopulmonary dysplasia (BPD), a chronic lung disease of preterm infants, is characterized by impaired alveolar growth and pathologic vascularization. This project aims to investigate the role of Fibroblast growth factor 10 (Fgf10) in hyperoxic lung injury. Methods: 10 weeks old Fgf10+/- mice (50% Fgf10 expression compared to WT) in normoxic condition: Lung function and morphometric analysis. BPD model: Fgf10+/- and Fgf10+/+ mice were exposed to 85% O2 from P0-P8. Morphometric analysis and α-Actin/vWF staining for vessels were performed at P3. Rosa26rtTA/+;tet(O)Fgf10 (gain-of-function) m…