A possible role of serotonin for the development of tobacco smoke-induced lung emphysema and pulmonary hypertension
A Pichl, M Seimetz, A Fysikopoulos, M Bednorz, N Parajuli, D Haag, R Reiter, J Grimminger, W Seeger, R Schermuly, F Grimminger, HA Ghofrani, N Weissmann · Pneumologie · 2014 · Heft 06
Bibliografische Angaben
Zusammenfassung
Chronic obstructive pulmonary disease (COPD) is a major cause of death and disability worldwide. An estimated portion of 30 – 70% of COPD patients also suffer from pulmonary hypertension (PH). Studies indicate that activation of serotonin-mediated pathways contribute to development of PH. Moreover, vascular alterations have been suggested to contribute to emphysema development. The aim of the study was to clarify the role of serotonin and the serotonin inhibitor Terguride on the development of tobacco smoke-induced emphysema and PH in a mouse model. WT mice (C57BL6/J) were exposed to cigarette smoke for 6 hours/…
