Miniaturization of the Organ Care System® into rat lungs for the establishment of ex-vivo therapy

Objectives: The Organ Care System® (OCS) is a well-established system used in human lung transplantation, allowing for warm perfusion and ventilation of the donor lungs. Besides lung retrieval, this system therefore offers an innovative opportunity for clinical ex-vivo therapy of diseased lungs for different indications, e.g. tumor therapy. While the patient is on extracorporeal membrane oxygenation, the otherwise inoperable lungs can be treated in the OCS, followed by autotransplantation. For the development of ex-vivo therapy, a miniaturized OCS for small animals model was established. Methods: Wistar rats wer…