Chitosan/Polycaprolactone electrospun biodegradable scaffolds for Cardiovascular Tissue Engineering

Introduction: Polycaprolactone (PCL) and chitosan (CS) are polymers with attractive properties (excellent biocompatibility & degradation). However their mechanical properties seperately do not satisfy the needs for cardiovascular tissue engineering. In the present work we aimed to optimize electrospinning parameters to obtain a flexible PCL/CS polymeric scaffold, with combined nano- and micro-fiber architecture and appropriate mechanical properties for cardiovascular tissue engineering in regenerative medicine. Methods: PCL and CS were dissolved in acetic acid (AAC) and 2,2,2-trifluroethanol (TFE) using differen…