NFATc1 -EGFR loop controls Sox9 promoter for Acinar ductal metaplasia
NM Chen, G Singh, L Regal, E Hessmann, S Baumgart, SK Singh, K Reutlinger, TM Gress, A König, V Ellenrieder · Zeitschrift für Gastroenterologie · 2014 · Heft 08
Bibliografische Angaben
Zusammenfassung
Introduction: Mutations of the oncogene KRAS are important drivers of pancreatic cancer progression. One of the main risk factors for the development of PDA in humans is chronic pancreatitis that induces the expression of EGFR and nuclear factor of activated T cells (NFAT). Recent evidence has shown KRAS-driven and pancreatitis-associated pancreatic tumor initiation is dependent on EGFR. The signaling pathways downstream of EGFR that mediate ADM are less clear. Aims: To explore the interaction of NFATc1 and EGFR signalling in acinar ductal metaplasia in the presence of Kras mutation. Methods: We generated mouse…
