P3NP-levels in patients with HIV/HCV-co-infection reflects fibrosis stage and hepatic venous pressure gradient
C Jansen, R Schierwagen, M Mandorfer, P Schwabl, E Anadol, CP Strassburg, M Peck-Radosavljevic, J Rockstroh, T Reiberger, J Trebicka · Zeitschrift für Gastroenterologie · 2014 · Heft 08
Bibliografische Angaben
Zusammenfassung
Background: The liver related deaths in patients with HIV/HCV-co-infection are increasing at least partially due to long-term consequences of fibrosis and portal hypertension. However, predictors of fibrosis progression in these patients are poorly investigated and new biomarkers are needed. Our aim was to evaluate extracellular matrix (ECM) degraded fragments in peripheral blood as a biomarker for fibrosis and portal hypertension in patient with HIV/HCV co-infection. Methods: Fifty-eight (nineteen female) patients with HIV/HCV-co-infection were included in this study. Hepatic venous pressure gradient (HVPG) was…
