Pharmacodynamic monitoring of immunosuppressive effects indicates reduced cyclosporine activity during telaprevir therapy

Drug interactions with immunosuppressive drugs are a mayor problem of protease inhibitor based antiviral triple therapy of Hepatitis C virus reinfection after liver transplantation. In this retrospective cohort study we analyzed biomarkers of immunosuppressive effects of cyclosporine A (CsA) by quantifying nuclear factor of activated T cells (NFAT)-regulated gene expression during telaprevir therapy in liver transplant patients. Further more, dose adjustment and blood concentrations of CsA as well as the clinical course were analyzed. We observed a clear impact of telaprevir not only on dose and blood concentrat…