Sodium butyrate and calcium propionate alleviate dextran sulfate sodium (DSS)-induced acute ulcerative colitis and modulate body weight in one-year-old female and male BALB/c mice

Background and Aims: Beside age-related physiological low secretion of body metabolism-regulating hormones and changes in energy expenditure, low level of enteric beneficial microbiome metabolites, as consequences of the intestinal dysbiosis, may contribute to body and abdominal fat accumulation a feature of middle and advance adult age, implicating for obesity and diabetes. Although DSS-induced murine model of colitis is frequently used to investigate the health benefits of probiotic bacteria and SCFA, there has been little research attempting to verify these effects, in particular calcium propionate, in middle…