Identification of the most effective chemotherapy in recurrent ovarian cancer using the spheroid model

Background and aims: Most ovarian cancer patients suffer relapse despite multimodal treatment. According to international guidelines a variety of drug options exist. The aim of the present study was the identification of the most effective chemotherapy for the individual ovarian cancer patient using the spheroid model. Treatment response pattern was correlated with the cellular and molecular characteristics of the individual tumor. Patients and methods: Spheroids were directly generated from fresh tumor tissues (n = 33) and tested for a variety of guideline recommended therapeutic options. Efficacy of the drugs…