Knockdown of TRAIL-R2 in breast cancer cells impairs bone metastases formation in a preclinical mouse model
T Heilmann, H Fritsche, R Towers, G Campbell, M Rauner, C Hauser, S Tiwari, W Jonat, C Schem, H Kalthoff, A Trauzold · Geburtshilfe und Frauenheilkunde · 2014 · Heft 09
Bibliografische Angaben
Zusammenfassung
Introduction: Plasma-membrane localized death receptors TRAIL-R1/R2 induce apoptosis and pro-inflammatory responses when crosslinked by their ligand TRAIL. In its nuclear localization TRAIL-R2 promotes cell proliferation by regulating the maturation of miRNA let-7. Interestingly, overexpression of TRAIL-R2 has been correlated with worse prognosis for patients with breast cancer, which is known to frequently metastasize to the bone. In the present study, using a preclinical mouse model, we analyzed the impact of TRAIL-R2 on the ability of breast cancer cells to form bone metastases. Methods: Bone seeking MDA-MB-2…
