Increased chromosome 16 disomy rates in human spermatozoa associated with recurrent miscarriages

Introduction: The male contribution in the aetiology of recurrent spontaneous abortions (RSA) is under debate. “Sperm-FISH” data on RSA-males are rare and limited to chromosomes 13,18,21,X and Y. Nevertheless, current data indicate that these patients may have elevated gonosomal disomy rates as well increased cumulative aneuploidy frequencies in spermatozoa. We investigated whether unexplained RSA are associated with increased rates of aneuploidy in spermatozoa of RSA-males. As numeric chromosomal aberrations in chromosomes other than 13,18,21,X and Y have been shown to be relevant in pregnancy loss, for the fir…