MCP-1 – a critical inducer of Smac mimetic-induced migration and invasion in glioma cells

The highly malignant glioblastoma is the most frequent brain tumor and has a very poor prognosis with a very short median survival. Its aggressiveness especially in migration and invasion has been linked, beside others, to constitutively activated NF-κappaB (NF- κB). Inhibitor of apoptosis (IAP) proteins are often overexpressed in different cancer entities and associated with therapy resistance and poor prognosis. The majority of glioblastoma cell lines highly express IAP proteins. IAP proteins are antagonized by second mitochondria -derived activator of caspases (Smac) released from mitochondria during apoptosi…