Loss of Integrin-β1 in Hepatocytes Induces Liver Fibrosis

Background and Aims: Integrins are receptors located on cell surfaces that mediate the interaction between cells and the extracellular matrix (ECM) by directly binding components of the ECM like fibronectin and collagen. Integrin-β1 is a major integrin subunit that is involved in a variety of vital functions resulting in embryonal lethality in knockout mice. In the liver, integrin β1 was shown to support liver regeneration. Further, in vitro studies have shown that it supports matrix turnover. We therefore asked whether integrin β1 might affect the amount of matrix produced or accumulating in the matrix under ph…