Regulation of energy metabolism in hepatocytes with induced steatosis

Mitochondria are cellular organelles involved in variety of metabolic pathways and important for ATP production. Based on our new findings the Hedgehog (Hh) signaling pathway is an active pathway in healthy mature hepatocytes with relevant impact on endocrine liver function and is involved in lipid metabolism [1,2]. In this study we explored the effects of nutritive induced steatosis in combination with hepatocyte-specific deletion of Hh signaling transcription factor Gli3 on the regulation of energy metabolism in mitochondria. For this analysis we used a transgenic mouse model with deletion of Gli3 (KO) and fed…