Methylome screen identifies epigenetically deregulated microRNAs in cholangiocarcinoma
B Goeppert, C Ernst, C Baer, A Mehrabi, M Hafezi, M Renner, A Warth, A Stenzinger, W Weichert, P Schirmacher, C Plass, D Weichenhan · Zeitschrift für Gastroenterologie · 2015 · Heft 01
Bibliografische Angaben
Zusammenfassung
Background & Aims: The molecular mechanisms, in particular epigenetic alterations, underlying the genesis of cholangiocarcinomas (CC) are poorly understood. We have previously shown data of global methylation changes in CC. Here, we focus on specific microRNAs (miRNAs) that showed drastic methylation alterations in our methylome screen. Methods: Data of a previously presented genome-wide analysis that identified differentially methylated regions (DMRs) in 18 human CCs were used. Candidate miRNAs were selected by a previously described in silico analysis and technically confirmed by quantitative MassARRAY® analys…
