Relevance of organic cation transporter OCT1 (SLC22A1) in Diethylnitrosamine-initiated and Phenobarbital-promoted hepatocellular carcinoma in OCT3- knockout mice
J Knapstein, P Fuchs, G Daniel, F Darstein, J Marquardt, M Sprinzl, J Schattenberg, MA Wörns, A Lautem, M Hoppe-Lotichius, H Lang, PR Galle, T Zimmermann · Zeitschrift für Gastroenterologie · 2015 · Heft 01
Bibliografische Angaben
Zusammenfassung
Background: Organic cation transporters (OCT) are responsible for the uptake and intracellular inactivation of a broad spectrum of endogenous substrates. OCTs became pharmaceutically interesting, because they are determinants of the cytotoxicity of platin derivates and the transport activity has been shown to correlate with the sensitivity of tumors towards tyrosine kinase inhibitors. Recent data have shown a down-regulation of OCT1 (SLC22A1) and OCT3 (SLC22A3) in human hepatocellular carcinoma (HCC) and human cholangiocarcinoma (CCC), associated with tumor progression and a worse patient survival. The OCT1 down…
