Broad and cross-genotype-specific T cell responses during acute hepatitis E virus infection
A Gisa, SP Ventaka, P Behrendt, S Pischke, B Bremer, MP Manns, M Cornberg, H Wedemeyer, A Kraft · Zeitschrift für Gastroenterologie · 2015 · Heft 01
Bibliografische Angaben
Zusammenfassung
Background and aims: Hepatitis E is an inflammatory liver disease caused by infection with the hepatitis E virus (HEV). In tropical regions HEV is epidemic and predominantly mediated by HEV genotype 1 and 2 with > 3 million symptomatic cases per year and around 70,000 deaths. In Europe and America the zoonotic HEV genotype 3 and 4 have been predominantly reported. Whereas only 500 cases have been registered at the Robert-Koch-Institute in 2013, it has been estimated that approximately 17% of the population in Germany were exposed to HEV. Little is known about T cell responses during acute HEV infection. Therefor…
