CareLit Fachartikel

Tiotropium Respimat: Comparison of bronchodilator efficacy of 5 and 2.5 µg doses

J Hohlfeld, P Calverley, M Könen-Bergmann, N Metzdorf, S Bell · Pneumologie · 2015 · Heft 02

Dokument
1053513
CareLit-ID
Jahr
2015
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Pneumologie
Autor:innen
J Hohlfeld, P Calverley, M Könen-Bergmann, N Metzdorf, S Bell
Ausgabe
Heft 02 / 2015
Seiten
–
Erschienen: 2015-02-04 00:00:00
ISSN
0934-8387
DOI
10.1055/s-0035-1544635

Zusammenfassung

Background: Safety and efficacy of tiotropium Respimat 5 µg (R5) and 2.5 µg (R2.5) doses were compared with tiotropium HandiHaler 18 µg (HH) in two recent chronic obstructive pulmonary disease (COPD) trials. Aims and objectives: To compare bronchodilator efficacy of once-daily R5 and R2.5 and HH in TIOtropium Safety and Performance In Respimat (TIOSPIR; NCT01126437)1 and the 205.458 (NCT01222533)2 trials. Methods: TIOSPIR: Randomized, double-blind (n= 17,135; mean 2.3 years' follow up) trial assessing mortality and exacerbations. Included a spirometry substudy (n= 1370), predefined test of noninferiority of R5 a…

Schlagworte

Pneumologie