IL-1beta release in human lung tissue and mononuclear cells is dependent on pneumococcal pneumolysin
DG Fatykhova, A Rabes, C Machnik, A Becher, J Berg, M Toennies, TB Torsten, P Schneider, J Rueckert, J Neudecker, N Suttorp, S Hippenstiel, B Opitz, AC Hocke · Pneumologie · 2015 · Heft 04
Bibliografische Angaben
Zusammenfassung
Streptococcus pneumoniae (S.p.) is a major cause of pneumonia, bacteremia, sepsis and meningitis worldwide. More than 90 S.p. serotypes are classified, which greatly differ in invasiveness, colonization and disease severity. One major virulence factor of S.p. is pneumolysin (PLY), a cholesterol-dependent pore-forming toxin with cytolytic effects. Recent research revealed that differences in its hemolytic activity contribute to carriage prevalence of bacteria and, moreover, may be highly relevant for the regulation of lung injury. PLY induces immune responses by enhancing cytokine secretion, including NLRP3 infla…
