The adiponectin paralog CTRP9 but not CTRP7 mediates anti-oxidative effects in adult rat cardiomyocytes through an AMPK, adiponectin receptor and calreticulin dependent mechanism
L Li, D Stumpp, B Siegler, M Micoogullari, B Niemann, M Aslam, H Bugger, H Jakoub, KD Schlüter, RE Silber, S Rohrbach · Diabetologie und Stoffwechsel · 2015 · Heft 04
Bibliografische Angaben
Zusammenfassung
Background: The adipokine adiponectin has direct beneficial effects on cardiomyocytes. However, obesity and ageing are characterized by an adiponectin deficit. Recently, a family of adiponectin paralogs, comprising 15 members so far, was discovered and designated as C1q/tumor necrosis factor-alpha-related proteins (CTRPs). While the protective adiponectin actions are well recognized, questions remain unanswered concerning the role of the CTRPs. Methods and Results: Among all adiponectin paralogs, CTRP7 and CTRP9 are induced in failing human hearts. CTRP9, which is expressed in adult human cardiomyocytes, protect…
