Identification of a quantitative trait locus effecting liver fat content and blood glucose in an NZOxB6 backcross
A Kamitz, N Hallahan, R Burkhardt, G Schulze, M Jähnert, D Arends, R Kluge, HG Joost, A Schürmann · Diabetologie und Stoffwechsel · 2015 · Heft 04
Bibliografische Angaben
Zusammenfassung
Background: The New Zealand Obese (NZO) mouse is a model of human obesity and type 2 diabetes and therefore suitable for the identification of disease genes by positional cloning. The aim was to identify novel diabetes genes and suppressors in a backcross population of the NZO with the diabetes resistant C57BL/6J (B6) mouse. Methods: Of the backcross population 600 mice on high-fat diet (45% fat) were intensively phenotyped (body weight and composition, blood glucose, insulin sensitivity) and genotyped for 140 polymorphic SNPs in order to perform linkage analysis for mapping distinct quantitative trait loci (QTL…
