Muscle- and liver-specific alterations in lipid and acylcarnitine metabolism after a single bout of exercise in mice

The accumulation of certain lipids in non-adipose tissues has been associated with metabolic disorders like insulin resistance and type 2 diabetes. Intracellular lipid pools are highly dynamic and tissue specific. While it is reasonable to expect differences in the regulation of lipid species between organs like liver and muscle, less attention is usually paid to the distinct metabolism of individual skeletal muscles. The plantar flexors gastrocnemius and soleus differ greatly in their content of slow, oxidative fibres, particularly in mice, the most important metabolic animal model. We studied the acute regulat…