Metabolomics profiling identifies long-chain phosphatidyl-cholines as a potential causative link between iron and insulin resistance in NAFLD
L Stechemesser, D Niederseer, A Wagner, T Felder, A Stadlmayr, S Eder, M Strasser, C Datz, E Aigner · Zeitschrift für Gastroenterologie · 2015 · Heft 05
Bibliografische Angaben
Zusammenfassung
Background: Elevated serum ferritin has been linked NAFLD and adverse outcomes in subjects with the Metabolic Syndrome (MetS). As the mechanisms underlying the negative impact of excess iron have so far remained elusive, we aimed to identify potential pathways using a metabolomics analysis. Methods: In all subjects, a detailed clinical and biochemical characterization was obtained. Metabolomics profiling was performed in patients with MetS with (n = 56) and without iron overload (n = 54) and a lean, healthy control group (n = 53) utilizing the AbsoluteIDQ™ p180 kit (BIOCRATES Life Sciences AG). Significant diffe…
