Eukaryotic Translation Initiation Factors in Gastroenteropancreatic Neuroendocrine Tumors – A TMA based Study

Eukaryotic translation initiation factors (eIFs) are mediators of start codon recognition in eukaryotes. If activated aberrantly, they might alter cell growth and proliferation, and thus contribute to carcinogenesis. In the course of the neuroendocrine tumor (NET)-study project at the Medical University of Graz, we have analyzed various eIF subunits in gastroenteropancreatic (GEP)-NETs in a tissue microarray (TMA)-based immunohistochemical study. To the best of our knowledge, not much is yet known about eIFs in NETs in literature, and thus we aimed to gain knowledge about their expression patterns. We have inves…