Changes in renal function parameters during nucleos(t)ide analogues (NA) treatment in patients with chronic hepatitis B
C Freissmuth, S Beinhardt, R Stern, K Kozbial, M Eder, AF Stättermayer, M Trauner, P Ferenci, H Hofer · Zeitschrift für Gastroenterologie · 2015 · Heft 05
Bibliografische Angaben
Zusammenfassung
Background & aim: Telbivudine (LdT), Tenofovir (TDF) and Entecavir (ETV) are nucleos(t)ide analogues (NA) for the treatment of chronic hepatitis B (CHB). Whereas, impairment of renal function is of concern in long-term treatment with TDF, LdT has been reported to be associated with beneficial effects on renal function. Aim of this study was to evaluate renal function parameters in patients with CHB during treatment with NA. Patients & methods: A total of 133 CHB patients (m/f = 99/34, mean age: 40.7 ± 12.2 years (mean ± SD), HBV-genotype D: 57%) treated with ETV (n = 30), LdT (n = 39) and TDF (n = 64) were retro…
