Impact of embryonic Fgf10 expression deficiency on embryonic mouse lung development and hyperoxia lung injury

Introduction: Bronchopulmonary dysplasia (BPD), a chronic lung disease of preterm infants, is characterized by impaired alveolar growth and pathologic vascularization. We investigate the impact of Fgf10 expression deficiency on embryonic lung development and hyperoxia lung injury (BPD mouse model). Methods: Embryonic lungs (Fgf10+/- and Fgf10+/+[WT]) were harvested at E12.5 and E18.5. Lung branches were quantified and H&E staining was performed. After BrdU labeling lungs were harvest from embryos at E12.5. BrdU staining was performed on paraffin-embedded sections. Transcriptomic analyses were performed by using…