Preserved right ventricular function in mitochondrial uncoupling protein 2 deficient mice in pressure overload induced right ventricular insufficiency
A Esfandiary, N Sommer, O Pak, B Kojonazarov, A Sydykov, D Haag, M Hecker, W Seeger, HA Ghofrani, R Schermuly, N Weissmann, R Schulz, R Schreckenberg, KD Schlüter · Pneumologie · 2015 · Heft 07
Bibliografische Angaben
Zusammenfassung
Right ventricular (RV) insufficiency is caused by RV pressure overload, when mechanisms compensating the increased afterload cannot maintain RV function. Similar to the left ventricle, compensatory and decompensatory mechanisms may be regulated by cellular calcium dynamics and reactive oxygen species (ROS). The mitochondrial uncoupling protein 2 (UCP2) can regulate mitochondrial calcium and ROS, and thus may interfere with development of RV insufficiency. RV pressure-overload was induced in UCP2-KO and wild type (WT) mice by pulmonary arterial banding (PAB). Three weeks after PAB or sham operation RV function wa…
