Effectiveness, safety and cost per sustained virological response in Hepatitis C patients treated with Sofosbuvir based therapies in clinical practice in Germany

Introduction: Real-world (RW) clinical outcomes of sofosbuvir (SOF)-based treatment from Germany have recently been presented but no study to date has evaluated these economic outcomes. The aim of this study was to estimate the total costs, RW effectiveness, safety and cost per sustained viral response (SVR) of chronic hepatitis C (CHC) patients treated with SOF-based therapies in Germany. Materials and Methods: A retrospective single centre cohort study was conducted. The first 159 sequential CHC adult patients treated with SOF-based therapies were included. SVR rates (ITT), overall and per subgroup including t…