CareLit Fachartikel

The INFORM-study for personalized pediatric oncology: current status and future outlook

O Witt, C van Tilburg, B Worst, R Witt, DT Jones, P Lichter, A Eggert, SM Pfister · Klinische Pädiatrie · 2015 · Heft 11

Dokument
1054246
CareLit-ID
Jahr
2015
Publikation
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Bibliografische Angaben

Zeitschrift
Klinische Pädiatrie
Autor:innen
O Witt, C van Tilburg, B Worst, R Witt, DT Jones, P Lichter, A Eggert, SM Pfister
Ausgabe
Heft 11 / 2015
Seiten
–
Erschienen: 2015-11-24 00:00:00
ISSN
0300-8630
DOI
10.1055/s-0035-1564675

Zusammenfassung

Introduction: Relapsed high grade malignancies in children have a fatal prognosis requiring novel treatment concepts. We have launched the national INFORM (Individualized Therapy for Children with Relapsed Malignancies) program to address this unmet medical need within the GPOH. Methods: Within the Pilot Phase and first 2 months of the INFORM-Registry study, relapsed tumors of > 70 patients have been analyzed using the INFORM diagnostic pipeline. This includes WES, WGS, RNASeq, 450K DNA methylation and RNA expression profiling. Results: The majority of INFORM cohort patients suffer from relapsed brain tumors or…

Schlagworte

Klinische Pädiatrie