CareLit Fachartikel

A disintegrin and metalloprotease 10 (ADAM10) is a central regulator of liver tissue homeostasis

M Müller, S Wetzel, J Köhn-Gaone, K Chalupsky, R Lüllmann-Rauch, R Barikbin, B Wöhner, G Tiegs, S Rose-John, R Sedlacek, JEE Tirnitz-Parker, P Saftig, D Schmidt-Arras · Zeitschrift für Gastroenterologie · 2015 · Heft 12

Dokument
1054323
CareLit-ID
Jahr
2015
Publikation
PDF
nein
Metadaten
DOI
ja
zitierfähig

Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
M Müller, S Wetzel, J Köhn-Gaone, K Chalupsky, R Lüllmann-Rauch, R Barikbin, B Wöhner, G Tiegs, S Rose-John, R Sedlacek, JEE Tirnitz-Parker, P Saftig, D Schmidt-Arras
Ausgabe
Heft 12 / 2015
Seiten
–
Erschienen: 2015-12-14 00:00:00
ISSN
0044-2771
DOI
10.1055/s-0035-1567935

Zusammenfassung

A Disintegrin And Metalloprotease (ADAM) 10 exerts essential roles during organ development and tissue integrity in many organs. However, only little is known about its implication in liver tissue physiology. We therefore generated mice deficient for Adam10 in hepatocytes, cholangiocytes and liver progenitor cells. While biliary tree formation and bile canaliculi morphology was normal in ADAM10Δhep/Δch animals, we observed areas with hepatocyte necrosis. This correlated with an impaired expression of bile acid transporters. Decreased numbers of necrotic areas in 15-week old ADAM10Δhep/Δch mice were clear evidenc…

Schlagworte

Zeitschrift für Gastroenterologie