Identification of transcriptional regulatory networks in acute liver damage and regeneration

Acute liver injury triggers a myriad of signaling and transcriptional events, including stress and inflammatory transcriptional regulatory networks (TRN). These pathways may exacerbate damage or promote regeneration, depending on factors such as timing, duration, intensity and crosstalk. To identify TRN induced early and late after hepatotoxic exposure, we analyzed mouse liver tissue after a single CCl4 administration (1.6 g/kg) using Affymetrix gene arrays and bioinformatics, combined with histological and western blot analyses, at early (2h, 8h), intermediate (1, 2, 4 days) and late time points (8 and 16 days)…