FUT2 variant might modulate the course in secondary sclerosing cholangitis in critically ill patients (SC-CIP)

Background and Aim: Variants in the FUT2 gene, which encodes a fucosyltransferase enzyme, have previously been associated with primary sclerosing cholangitis (rs601338) and plasma vitamin B12 levels (rs492602). Of note, these variants are in linkage disequilibrium and altered vitamin B12 levels seem to be associated with mortality in lCU patients (Sviri et al. Clin Nutr 2012). Secondary sclerosing cholangitis in critically ill patients (SC-CIP) is a progressive cholestatic disease with unknown pathophysiology with dismal prognosis. We hypothesized that FUT2 variants, which influenced plasma vitamin B12 levels in…