Hepatic gene expression profile characterizes high levels of liver regeneration related genes in nonalcoholic fatty liver disease

Nonalcoholic fatty liver disease (NAFLD) is a chronic hepatic disease caused by abnormal or excessive accumulation of fat in hepatocytes. NAFLD covers a spectrum of liver disorders ranging from simple steatosis (S) to nonalcoholic steatohepatitis (NASH) and cirrhosis, and is associated with changes in gene expression profiles. Tissue gene expression profiling has been precious for developing diagnostic and predictive biomarkers as well as for improving therapeutical strategies in many diseases. Therefore, the aim of this study was to use microarray analysis to characterize a liver gene expression profile that di…