HCV-specific immune responses under direct-acting antiviral therapy of chronic HCV infection
C Dembek, C Russo, A Grambihler, J Schattenberg, T Zimmermann, T Bauer, A Weinmann, PR Galle, U Protzer, MF Sprinzl · Zeitschrift für Gastroenterologie · 2015 · Heft 12
Bibliografische Angaben
Zusammenfassung
Background: Direct-acting antiviral drugs (DAA) with or without Ribavirin or PEG-Interferon-alpha efficiently suppress and clear hepatitis C virus (HCV) infection. However, it remains controversial if robust HCV suppression also affects viral immune-escape and restores HCV-directed adaptive immune responses in vivo. Methods: In order to address these issues we monitored HCV-specific T-cell response from 20 chronically HCV infected patients throughout treatment with Sofosbuvir, Ribavirin and PEG-Interferon-alpha. HCV-specific CD4 and CD8 T-cell responses were identified by ex vivo HCV epitope pool stimulation and…
