Safety, tolerability and clinical effects of a rapid dose titration of subcutaneous treprostinil therapy in pulmonary arterial hypertension: a prospective multi-centre trial.
B Egenlauf, E Grünig, N Benjamin, TJ Lange, U Krüger, HF Klose, C Neurohr, H Wilkens, M Halank, HJ Seyfarth, M Held, A Traube, M Pernow, RE Grover, F Gerhardt, T Viethen, S Rosenkranz · Pneumologie · 2016 · Heft 02
Bibliografische Angaben
Zusammenfassung
Background: The objective of this open label, multi-centre study was to evaluate safety, tolerability and clinical effects of a rapid up-titration dosing regimen of subcutaneous (SC) treprostinil using pro-active infusion site pain management in patients with severe pulmonary arterial hypertension (PAH). Methods: Safety and tolerability were assessed by adverse events and discontinuation rate. Clinical parameters and right heart catheterisation were performed at baseline and after 16 weeks. Results: Thirty-nine patients with idiopathic, heritable or drug-induced PAH who were on stable treatment with oral PAH app…
