Effect of stretching on PLTP secretion in alveolar epithelial TypII cell

Background: Phospholipid transfer protein (PLTP) facilitates the transfer of a spectrum of different lipid molecules, not only in the vascular compartment, but also in a variety of tissues. It is highly expressed within the lung epithelium. Alterations in lung lipid metabolism precede the development of fibrosis, at the same time inflammation likely plays a role in disease genesis and progression. Increased mechanical stretching is also able to cause pulmonary fibrosis by epithelial injury. Aims and objectives: We have investigated the association between PLTP secretion and stretching of alveolar epithelial TypI…